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Human,squamous cell lung cancer,LC-MS/MS

ABSTRACT: We compared the proteome of primary SqCLC tumor tissue between patients with ER (< 10 months) vs. LR (> 30 months) following surgery. iTRAQ-based quantitative 2D LC-MS/MS proteomics were performed on 20 SqCLC tumor samples (10 ER, 10 LR) using a matched pair design in which each ER tumor sample was paired and analyzed together with a LR tumor sample matched based on similar patient clinicopathologic features, including gender, smoking history, age and TNM status.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

DISEASE(S): Lung Squamous Cell Carcinoma

SUBMITTER: Qingqing Wu

LAB HEAD: Henrik J. Ditzel

PROVIDER: PXD009383 | Pride | 2021-09-08

REPOSITORIES: Pride

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			Action	DRS
	1F_1.dat	Other
	1F_2.dat	Other
	1F_3.dat	Other
	1F_4.dat	Other
	1F_5.dat	Other

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Publications

DDX56 modulates post-transcriptional Wnt signaling through miRNAs and is associated with early recurrence in squamous cell lung carcinoma.

Wu Qingqing Q Luo Xiaoyang X Terp Mikkel G MG Li Qingrun Q Li Yuan Y Shen Lei L Chen Ying Y Jacobsen Kirstine K Bivona Trever G TG Chen Haiquan H Zeng Rong R Ditzel Henrik J HJ

Molecular cancer 20210826 1

<h4>Background</h4>Early recurrence is a major obstacle to prolonged postoperative survival in squamous cell lung carcinoma (SqCLC). The molecular mechanisms underlying early SqCLC recurrence remain unclear, and effective prognostic biomarkers for predicting early recurrence are needed.<h4>Methods</h4>We analyzed primary tumor samples of 20 SqCLC patients using quantitative proteomics to identify differentially-expressed proteins in patients who experienced early versus late disease recurrence. ...[more]

PMID: 34446021

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| phs000472 | dbGaP

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