Proteomics

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CTDP1 BRCT domain PPI - CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI

ABSTRACT: The BRCT domain is commonly found in DNA damage response proteins, but its role in the phosphatase CTDP1 is unknown. This project examined the protein-protein interactions (PPI) associated with the CTDP1 BRCT domain region only and identified 106 significant interacting partners. Many of these partners play prominent roles in distinct DNA damage repair pathways and reveal novel functions of CTDP1 in these pathways.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

SUBMITTER: Nicholas Woods  

LAB HEAD: Nicholas T. Woods, Ph.D.

PROVIDER: PXD009541 | Pride | 2019-06-04

REPOSITORIES: Pride

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01232014_Woods_2-1_01.RAW Raw
01232014_Woods_2-1_01.RAW (F028752).mzid_01232014_Woods_2-1_01.RAW_(F028752).pride.mgf.gz Mzid
01232014_Woods_2-1_01.RAW (F028752).pride.mztab.gz Mztab
01232014_Woods_2-1_01.RAWF028752.mzid.gz Mzid
01232014_Woods_2-1_01.RAWF028752.mzid_01232014_Woods_2-1_01.RAW_F028752.MGF Mzid
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Publications

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

Hu Wen-Feng WF   Krieger Kimiko L KL   Lagundžin Dragana D   Li Xueli X   Cheung Ronald S RS   Taniguchi Toshiyasu T   Johnson Keith R KR   Bessho Tadayoshi T   Monteiro Alvaro N A ANA   Woods Nicholas T NT  

Cell death discovery 20190619

BRCA1 C-terminal domains are found in a specialized group of 23 proteins that function in the DNA damage response to protect genomic integrity. C-terminal domain phosphatase 1 (CTDP1) is the only phosphatase with a BRCA1 C-terminal domain in the human proteome, yet direct participation in the DNA damage response has not been reported. Examination of the CTDP1 BRCA1 C-terminal domain-specific protein interaction network revealed 103 high confidence interactions enriched in DNA damage response pro  ...[more]

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