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Proteomic analysis of extracellular vesicles (EVs) from 4T1 breast cancer cells upon paclitaxel treatment

ABSTRACT: Increasing pre-clinical data suggest that chemotherapy may elicit pro-metastatic responses in breast cancer models. Primary tumours release extracellular vesicles (EVs) that can facilitate the seeding and growth of metastatic cancer cells in distant organs, but the effects of chemotherapy on pro-metastatic EVs are poorly understood. The goal of the project was to analyse the protein content in EVs released by the mouse breast cancer cell line 4T1 after treatment with the chemotherapeutic agent paclitaxel (PTX) or its vehicle control cremophor (CREMO).

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Chiara Cianciaruso

LAB HEAD: Michele De Palma

PROVIDER: PXD010362 | Pride | 2019-01-02

REPOSITORIES: pride

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Dataset's files

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			Action	DRS
	IK_160321_Elite_4TI_Cremo_01.dta	Other
	IK_160321_Elite_4TI_Cremo_01.raw	Raw
	IK_160321_Elite_4TI_Cremo_02.dta	Other
	IK_160321_Elite_4TI_Cremo_02.raw	Raw
	IK_160321_Elite_4TI_PTX_01.dta	Other

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