Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Trypanosoma Brucei
SUBMITTER: Michele Tinti
LAB HEAD: Ian Gilbert
PROVIDER: PXD010409 | Pride | 2018-10-02
REPOSITORIES: Pride
Action | DRS | |||
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3911_F1_R1_P80505A01_TMT10.RAW.rar.F201778.dat | Raw | |||
3911_F1_R1_P80505A01_TMT10.raw | Raw |
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Webster Lauren A LA Thomas Michael M Urbaniak Michael M Wyllie Susan S Ong Han H Tinti Michele M Fairlamb Alan H AH Boesche Markus M Ghidelli-Disse Sonja S Drewes Gerard G Gilbert Ian H IH
ACS infectious diseases 20180928 10
The folate pathway has been extensively studied in a number of organisms, with its essentiality exploited by a number of drugs. However, there has been little success in developing drugs that target folate metabolism in the kinetoplastids. Despite compounds being identified which show significant inhibition of the parasite enzymes, this activity does not translate well into cellular and animal models of disease. Understanding to which enzymes antifolates bind under physiological conditions and h ...[more]