Proteomics

Dataset Information

0

β-TrCP and Casein Kinase II mediated degradation of cyclin F controls timely mitotic progression


ABSTRACT: Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. Checkpoint systems allow the accurate execution of each cell cycle phase. The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division with checkpoints, avoiding genome instability. Cyclin F has important functions in regulating the cell cycle during the G2 checkpoint; however, the mechanisms underlying the regulation of cyclin F are poorly understood. Here, we observe that cyclin F is regulated by proteolysis through β-TrCP. β-TrCP recognizes cyclin F through a non-canonical degron site (TSGXXS) after its phosphorylation by Casein Kinase II. The degradation of cyclin F mediated by β-TrCP occurs at the G2/M transition and this event is required to promote mitotic progression and favours the activation of a transcriptional programme required for mitosis.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Early Embryonic Cell, Kidney

DISEASE(S): Disease Free

SUBMITTER: Roman Fischer  

LAB HEAD: Roman Fischer

PROVIDER: PXD010737 | Pride | 2018-10-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
OTV3210_VCA_DOX.mgf Mgf
OTV3210_VCA_DOX.pride.mgf.gz Mgf
OTV3210_VCA_DOX.raw Raw
OTV3211_VCA_MLN.mgf Mgf
OTV3211_VCA_MLN.pride.mgf.gz Mgf
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Publications

β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression.

Mavrommati Ioanna I   Faedda Roberta R   Galasso Giovanni G   Li Jie J   Burdova Kamila K   Fischer Roman R   Kessler Benedikt M BM   Carrero Zunamys I ZI   Guardavaccaro Daniele D   Pagano Michele M   D'Angiolella Vincenzo V  

Cell reports 20180901 13


Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. Checkpoint systems allow the accurate execution of each cell-cycle phase. The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division with checkpoints, avoiding genome instability. Cyclin F has important functions in regulating the cell cycle during the G2 checkpoint; however, the mechanisms underlying the regulation of cyclin F are po  ...[more]

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