Dataset Information

Coral proteomics study - Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia)

ABSTRACT: Venoms from marine animals have been recognized as a new emerging source of peptide-based therapeutics. Several peptide toxins from sea anemone have been investigated as therapeutic leads or pharmacological tools. Venom complexity should be further confirmed using novel strategies of large-scale sequencing which integrated transcriptomics and proteomics to provide new putative proteins or peptides to be compared among species. We applied transcriptomic combining with proteomic analyses and identified six groups of peptide toxins including neurotoxin, hemostatic and hemorrhagic toxin, protease inhibitor, mixed function enzymes, venom auxiliary proteins, and peptides related to allergen and innate immunity.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Zoanthus Sp.

TISSUE(S): Whole Body

SUBMITTER: Qiwen Liao

LAB HEAD: Simon Ming-Yuen Lee

PROVIDER: PXD010839 | Pride | 2019-06-24

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20171215_Zoanthids.mgf	Mgf
	20171215_Zoanthids.msf	Msf
	20171215_Zoanthids_R1_12pt5ug.raw	Raw
	20171215_Zoanthids_R2_12pt5ug.raw	Raw
	20171215_Zoanthids_R3_12pt5ug.raw	Raw

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Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia).

Liao Qiwen Q Gong Guiyi G Poon Terence C W TCW Ang Irene L IL Lei Kate M K KMK Siu Shirley Weng In SWI Wong Clarence Tsun Ting CTT Rádis-Baptista Gandhi G Lee Simon Ming-Yuen SM

Archives of toxicology 20190615 6

Venoms from marine animals have been recognized as a new emerging source of peptide-based therapeutics. Several peptide toxins from sea anemone have been investigated as therapeutic leads or pharmacological tools. Venom complexity should be further highlighted using combined strategies of large-scale sequencing and data analysis which integrated transcriptomics and proteomics to elucidate new proteins or peptides to be compared among species. In this work, transcriptomic and proteomic analyses w ...[more]

PMID: 31203412

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