Proteomics

Dataset Information

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Somatostatin-interacting human brain proteins

ABSTRACT: Somatostatin (SST) is a cyclic peptide that is understood to inhibit the release of hormones and neurotransmitters from a variety of cells by binding to one of five canonical G protein-coupled SST receptors (SSTR1 to SSTR5). Recently, SST was observed to also interact with the amyloid beta (Aβ) peptide and affect its aggregation kinetics, raising the question which other brain proteins it can bind to. Here we report on an SST interactome analysis that made use of human brain extracts as biological source material and incorporated advanced mass spectrometry workflows for the relative quantitation of binders.

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Declan Williams  

LAB HEAD: Gerold Schmitt-Ulms

PROVIDER: PXD010885 | Pride | 2019-04-04

REPOSITORIES: Pride

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Dataset's files

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Action DRS
Humanbrain_SST_interactome_SST28_v_SST14_3_4_5_6_7_8_9control_1control_C18HighpH_1.raw Raw
Humanbrain_SST_interactome_SST28_v_SST14_3_4_5_6_7_8_9control_1control_C18HighpH_2.raw Raw
Humanbrain_SST_interactome_SST28_v_SST14_3_4_5_6_7_8_9control_1control_C18HighpH_3.raw Raw
Humanbrain_SST_interactome_SST28_v_SST14_3_4_5_6_7_8_9control_1control_C18HighpH_4.raw Raw
Humanbrain_SST_interactome_SST28_v_SST14_3_4_5_6_7_8_9control_1control_C18_1.raw Raw
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Publications

The human brain somatostatin interactome: SST binds selectively to P-type family ATPases.

Solarski Michael M   Williams Declan D   Mehrabian Mohadeseh M   Wang Hansen H   Wille Holger H   Schmitt-Ulms Gerold G  

PloS one 20190528 5

Somatostatin (SST) is a cyclic peptide that is understood to inhibit the release of hormones and neurotransmitters from a variety of cells by binding to one of five canonical G protein-coupled SST receptors (SSTR1 to SSTR5). Recently, SST was also observed to interact with the amyloid beta (Aβ) peptide and affect its aggregation kinetics, raising the possibility that it may bind other brain proteins. Here we report on an SST interactome analysis that made use of human brain extracts as biologica  ...[more]

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