Dataset Information

Human IPF and control lungs LC-MSMS

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 in lung epithelial cells in adult mice produces chronic lung disease that shares key features with IPF including progressive fibrosis and bronchiolization with increased expression of Muc5b in peripheral airways, honeycombing and characteristic alterations in the lung proteome

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

DISEASE(S): Pulmonary Fibrosis

SUBMITTER: Alexander Held

LAB HEAD: Ursula Klingmüller

PROVIDER: PXD011116 | Pride | 2020-03-20

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	170228_2_MSz-DD_F8-2_TCL_1360.raw	Raw
	170228_4_MSz-DD_F8-2_TCL_1330.raw	Raw
	170228_6_MSz-DD_F8-2_TCL_762.raw	Raw
	170301_10_MSz-DD_F8-2_TCL_5250.raw	Raw
	170301_14_MSz-DD_F8-2_TCL_3655.raw	Raw

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Publications

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.

Duerr Julia J Leitz Dominik H W DHW Szczygiel Magdalena M Dvornikov Dmytro D Fraumann Simon G SG Kreutz Clemens C Zadora Piotr K PK Seyhan Agircan Ayça A Konietzke Philip P Engelmann Theresa A TA Hegermann Jan J Mulugeta Surafel S Kawabe Hiroshi H Knudsen Lars L Ochs Matthias M Rotin Daniela D Muley Thomas T Kreuter Michael M Herth Felix J F FJF Wielpütz Mark O MO Beers Michael F MF Klingmüller Ursula U Mall Marcus A MA

Nature communications 20200424 1

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic options and poor prognosis. Here, we show that conditional deletion of the ubiquitin ligase Nedd4-2 (Nedd4l) in lung epithelial cells in adult mice produces chronic lung disease sharing key features with IPF including progressive fibrosis and bronchiolization with increased expression of Muc5b in peripheral airways, honeycombing and c ...[more]

PMID: 32332792

Dataset Information

Human IPF and control lungs LC-MSMS

Dataset's files

Publications

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.

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