Proteomics

Dataset Information

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Native mass spectrometry of calmodulin binding to the plasma-membrane Ca2+-ATPase ACA8


ABSTRACT: Binding of two calmodoulin proteins to the integral membrane protein ACA8, a plasma-membrane Ca2+-ATPase von A. thaliana, was shown by native mass spectrometry.

INSTRUMENT(S): Q-Tof ultima

ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress)

SUBMITTER: Johannes Heidemann  

LAB HEAD: Charlotte Uetrecht

PROVIDER: PXD011177 | Pride | 2018-12-05

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20150929J048_80_raw.txt Txt
20150929J048_80sm2x3.txt Txt
20150929J048_80sm2x3_fig.PNG Other
20150929J048_80sm2x3_settings.txt Txt
20150929J0542_174sm2x20.PNG Other
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Publications


Plasma-membrane Ca<sup>2+</sup>-ATPases expel Ca<sup>2+</sup> from the cytoplasm and are key regulators of Ca<sup>2+</sup> homeostasis in eukaryotes. They are autoinhibited under low Ca<sup>2+</sup> concentrations. Calmodulin (CaM)-binding to a unique regulatory domain releases the autoinhibition and activates the pump. However, the structural basis for this activation, including the overall structure of this calcium pump and its complex with calmodulin, is unknown. We previously determined the  ...[more]

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