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Ixodes scapularis chemotactic protein identification

ABSTRACT: Tick proteins within a fraction from medium pressure liquid chromatography were identified as potential chemoattractants for Borrelia burgdorferi. The proteins in two replicate fractions were identified using LC-MS/MS.

INSTRUMENT(S): nanoACQUITY UPLC

ORGANISM(S): Ixodes Scapularis (black-legged Tick) (deer Tick)

TISSUE(S): Salivary Gland

SUBMITTER: Kristen Murfin

LAB HEAD: Erol Fikrig

PROVIDER: PXD011273 | Pride | 2021-09-08

REPOSITORIES: Pride

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			Action	DRS
	QEp16-5797_Murfin_F3_1.raw	Raw
	QEp16-5797_Murfin_F3_1ixodesDB_F499082.xml	Xml
	QEp16-5801_Murfin_F3_2.raw	Raw
	QEp16-5801_Murfin_F3_2ixodesDB_F499096.xml	Xml

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Publications

Borrelia burgdorferi chemotaxis toward tick protein Salp12 contributes to acquisition.

Murfin Kristen E KE Kleinbard Ruby R Aydin Merve M Salazar Samuel A SA Fikrig Erol E

Ticks and tick-borne diseases 20190608 5

Lyme disease is a common tick-borne infection caused by the spirochete Borrelia burgdorferi sensu stricto (s.s.). B. burgdorferi s.s. may utilize chemotaxis, the directional migration towards or away from a chemical stimulus, for transmission, acquisition, and infection. However, the specific signals recognized by the spirochete for these events have not been defined. In this study, we identify an Ixodes scapularis salivary gland protein, Salp12, that is a chemoattractant for the spirochete. We ...[more]

PMID: 31204044

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