Proteomics

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Mucolytic activity of Akkermansia muciniphila enables Human Milk Oligosaccharides degradation.

ABSTRACT: This study was conducted in order to monitor whether or not Akkermansia muciniphila was able to grow and utilize human milk and human milk oligosaccharides by deploying its mucin degrading enzymes. Interestingly, A. muciniphila was able to grow in human milk producing Short Chain Fatty Acids and degrade milk oligosaccharides (2’-fucosyllactose, 3’-siallylactose) as well as lactose.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Akkermansia Muciniphila Atcc Baa-835

SUBMITTER: Sjef Boeren  

LAB HEAD: Sjef Boeren

PROVIDER: PXD011357 | Pride | 2020-09-07

REPOSITORIES: Pride

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IK41-64MaxQuantresult.zip Other
IK41_Mucin_M1a.raw Raw
IK42_Mucin_M1b2.raw Raw
IK43_Mucin_M1c.raw Raw
IK44_Mucin_M2a.raw Raw
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Publications

Akkermansia muciniphila uses human milk oligosaccharides to thrive in the early life conditions in vitro.

Kostopoulos Ioannis I   Elzinga Janneke J   Ottman Noora N   Klievink Jay T JT   Blijenberg Bernadet B   Aalvink Steven S   Boeren Sjef S   Mank Marko M   Knol Jan J   de Vos Willem M WM   Belzer Clara C  

Scientific reports 20200831 1

Akkermansia muciniphila is a well-studied anaerobic bacterium specialized in mucus degradation and associated with human health. Because of the structural resemblance of mucus glycans and free human milk oligosaccharides (HMOs), we studied the ability of A. muciniphila to utilize human milk oligosaccharides. We found that A. muciniphila was able to grow on human milk and degrade HMOs. Analyses of the proteome of A. muciniphila indicated that key-glycan degrading enzymes were expressed when the b  ...[more]

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