Dataset Information

Proteomic analysis of neutrophil extracellular traps (healthy control, rheumatoid arthritis, systemic lupus erythematosus)_C4PR_LIV

ABSTRACT: Neutrophil Extracellular Traps (NETs) are chromatin-derived extracellular structures that are expelled from neutrophils in response to infectious or inflammatory stimuli. NET DNA structures are decorated with proteins including histones, myeloperoxidase and neutrophil elastase. NETs are implicated in the development of auto-immunity in diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) through the externalisation of intracellular neoepitopes e.g. dsDNA and nuclear proteins in SLE and citrullinated peptides in RA. The aim of this work was to use quantitative proteomics to identify and measure NET proteins produced by neutrophils from healthy individuals, and from patients with RA and SLE.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Neutrophil, Blood

DISEASE(S): Systemic Lupus Erythematosus,Rheumatoid Arthritis

SUBMITTER: Deborah Simpson

LAB HEAD: Dr Helen L Wright

PROVIDER: PXD011796 | Pride | 2019-02-18

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	DS_181017_RA021_A23_1h.mgf	Mgf
	DS_181017_RA021_A23_1h.mzid.gz	Mzid
	DS_181017_RA021_A23_1h.pride.mgf.gz	Mgf
	DS_181017_RA021_A23_1h.pride.mztab.gz	Mztab
	DS_181017_RA021_A23_1h.raw	Raw

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Publications

Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus.

Chapman Elinor A EA Lyon Max M Simpson Deborah D Mason David D Beynon Robert J RJ Moots Robert J RJ Wright Helen L HL

Frontiers in immunology 20190311

Neutrophil Extracellular Traps (NETs) are implicated in the development of auto-immunity in diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) through the externalization of intracellular neoepitopes e.g., dsDNA and nuclear proteins in SLE and citrullinated peptides in RA. The aim of this work was to use quantitative proteomics to identify and measure NET proteins produced by neutrophils from healthy controls, and from patients with RA and SLE to determine if NETs ...[more]

PMID: 30915077

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