The flavonoid 4,4’-dimethoxychalcone promotes autophagy-dependent longevity across species
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: 
Joern Dengjel
LAB HEAD: Joern Dengjel
PROVIDER: PXD012108 | Pride | 2019-02-22
REPOSITORIES: Pride
Dataset's files
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| 20150210_ZH_MADEO51.raw | Raw | |||
| 20150210_ZH_MADEO52.raw | Raw | |||
| 20150210_ZH_MADEO53.raw | Raw | |||
| 20150210_ZH_MADEO54.raw | Raw | |||
| 20150210_ZH_MADEO55.raw | Raw |
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Publications
The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.
Carmona-Gutierrez Didac D Zimmermann Andreas A Kainz Katharina K Pietrocola Federico F Chen Guo G Maglioni Silvia S Schiavi Alfonso A Nah Jihoon J Mertel Sara S Beuschel Christine B CB Castoldi Francesca F Sica Valentina V Trausinger Gert G Raml Reingard R Sommer Cornelia C Schroeder Sabrina S Hofer Sebastian J SJ Bauer Maria A MA Pendl Tobias T Tadic Jelena J Dammbrueck Christopher C Hu Zehan Z Ruckenstuhl Christoph C Eisenberg Tobias T Durand Sylvere S Bossut Noélie N Aprahamian Fanny F Abdellatif Mahmoud M Sedej Simon S Enot David P DP Wolinski Heimo H Dengjel Jörn J Kepp Oliver O Magnes Christoph C Sinner Frank F Pieber Thomas R TR Sadoshima Junichi J Ventura Natascia N Sigrist Stephan J SJ Kroemer Guido G Madeo Frank F
Nature communications 20190219 1
Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4'-dimethoxychalcone (DMC) as a natural compound with anti-ageing properties. External DMC administration extends the lifespan of yeast, worms and flies, decelerates senescenc ...[more]
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