Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Bos Taurus (bovine)
TISSUE(S): Cumulus Cell, Oocyte
SUBMITTER: Kurt Boonen
LAB HEAD: Jo .L.M.R. Leroy
PROVIDER: PXD012141 | Pride | 2019-04-02
REPOSITORIES: Pride
Scientific reports 20190306 1
Maternal lipolytic metabolic disorders result in a lipotoxic microenvironment in the ovarian follicular fluid (FF) which deteriorates oocyte quality. Although cellular stress response mechanisms are well defined in somatic cells, they remain largely unexplored in oocytes, which have distinct organelle structure and nuclear transcription patterns. Here we used shotgun proteomic analyses to study cellular responses of bovine oocytes and cumulus cells (CCs) after in vitro maturation under lipotoxic ...[more]