Proteomics

Dataset Information

0

Proteomic changes in oocytes after in vitro maturation in lipotoxic conditions are different from those in cumulus cells


ABSTRACT: Sensitivity of cumulus enclosed-oocytes to metabolic stress during in vitro maturation. A proteomic insight

INSTRUMENT(S): Q Exactive

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Cumulus Cell, Oocyte

SUBMITTER: Kurt Boonen  

LAB HEAD: Jo .L.M.R. Leroy

PROVIDER: PXD012141 | Pride | 2019-04-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
TMT1.msf Msf
TMT1.raw Raw
TMT2.msf Msf
TMT2.raw Raw
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Publications

Proteomic changes in oocytes after in vitro maturation in lipotoxic conditions are different from those in cumulus cells.

Marei Waleed F A WFA   Van Raemdonck Geert G   Baggerman Geert G   Bols Peter E J PEJ   Leroy Jo L M R JLMR  

Scientific reports 20190306 1


Maternal lipolytic metabolic disorders result in a lipotoxic microenvironment in the ovarian follicular fluid (FF) which deteriorates oocyte quality. Although cellular stress response mechanisms are well defined in somatic cells, they remain largely unexplored in oocytes, which have distinct organelle structure and nuclear transcription patterns. Here we used shotgun proteomic analyses to study cellular responses of bovine oocytes and cumulus cells (CCs) after in vitro maturation under lipotoxic  ...[more]

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