Dataset Information

RTNs and DP1 Knockdown in neurons

ABSTRACT: Quantitative proteomics results of RTNs-KD neurons or DP1-KD neurons (DIV5). Peptides derived from Untreated neurons (UNT) were chemically labeled with TMT-126, pSuper-neurons with TMT-127, shRNAs_RTNs-neurons with TMT-128 and shRNA_DP1-neurons with TMT-131.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Riccardo Stucchi

LAB HEAD: Casper Hoogenraad

PROVIDER: PXD012264 | Pride | 2019-02-15

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20170630_OR12_Ag5_RS_F1.raw	Raw
	20170630_OR12_Ag5_RS_F2.raw	Raw
	20170630_OR12_Ag5_RS_F3.raw	Raw
	20170630_OR12_Ag5_RS_F4.raw	Raw
	20170630_OR12_Ag5_RS_F5.raw	Raw

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Publications

Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity.

Farías Ginny G GG Fréal Amélie A Tortosa Elena E Stucchi Riccardo R Pan Xingxiu X Portegies Sybren S Will Lena L Altelaar Maarten M Hoogenraad Casper C CC

Neuron 20190213 1

Establishment of neuronal polarity depends on local microtubule (MT) reorganization. The endoplasmic reticulum (ER) consists of cisternae and tubules and, like MTs, forms an extensive network throughout the entire cell. How the two networks interact and control neuronal development is an outstanding question. Here we show that the interplay between MTs and the ER is essential for neuronal polarity. ER tubules localize within the axon, whereas ER cisternae are retained in the somatodendritic doma ...[more]

PMID: 30772082

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