Dataset Information

Quantitative protein profiling of brain vessels in rhesus macaque

ABSTRACT: Aging is a major risk factor for cerebrovascular disease. However, the molecular mechanisms of cerebrovascular aging remain to be clarified. In this study, we performed proteomics analysis aimed to reveal the molecular signaling pathways during aging.our study demonstrated that the imbalance of vasodilators and vasoconstrictors caused by downregulation of NOS3, oxidative stress mediated by the suppression of NRF2 pathway, and miRNA-regulated accumulation of ECM proteins were critical for cerebrovascular aging.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Macaca Mulatta (rhesus Macaque)

TISSUE(S): Blood Vessel

SUBMITTER: Wei Ge

LAB HEAD: Wei Ge

PROVIDER: PXD012306 | Pride | 2019-11-13

REPOSITORIES: Pride

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Publications

Proteome Profiling of Cerebral Vessels in Rhesus Macaques: Dysregulation of Antioxidant Activity and Extracellular Matrix Proteins Contributes to Cerebrovascular Aging in Rhesus Macaques.

Wang Xia X Liu Yifan Y Jia Yangjie Y Liu Haotian H Bao Xinjie X He Zhanlong Z Ge Wei W

Frontiers in aging neuroscience 20191023

Aging is a major risk factor for cerebrovascular disease; however, the molecular mechanisms of cerebrovascular aging remain to be clarified. The aim of this study was to reveal the molecular signaling pathways involved in cerebrovascular aging. This study used high-resolution liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), in combination with quantitative 6-plex tandem mass tag labeling, to profile protein changes in brain vessels from three groups of healthy rhesus macaque ...[more]

PMID: 31708766

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