Comparison of proteome alternations during aging in temporal lobe from human and rhesus macaque
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Macaca Mulatta (rhesus Macaque)
TISSUE(S): Brain
SUBMITTER: 
Wei Ge
LAB HEAD: Wei Ge
PROVIDER: PXD013597 | Pride | 2020-06-25
REPOSITORIES: Pride
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Publications
Comparison of proteome alterations during aging in the temporal lobe of humans and rhesus macaques.
Wang Xia X Chen Kang K Pan Meng M Ge Wei W He Zhanlong Z
Experimental brain research 20200622 9
Rhesus macaques are widely used as animal models for studies of the nervous system; however, it is unknown whether the alterations in the protein profile of the brain during aging are conserved between humans and rhesus macaques. In this study, temporal cortex samples from old and young humans (84 vs. 34 years, respectively) or rhesus macaques (20 vs. 6 years, respectively) were subjected to tandem mass tag-labeled proteomic analysis followed by bioinformatic analysis. A total of 3861 homologous ...[more]
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