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A comprehensive protein profile analysis from clinical Sialoliths and its practical implications

ABSTRACT: We analyzed 29 Sialolith samples, employing classical Population Genetic principles (Hartl and Clark 1980 (1), Hahn 2018 (2)) and Systems Biology analysis (ed: by Rigoustsos and Stephanopoulos 2006 (3)) approaches to create specific algorithms designed for our research objectives. Using these methodologies, specific unknowns such as the intrinsic variability of salivary stones, the role that protein matrix plays in the structure and evolution of the stones, and the nature of their interaction with the inorganic phase were addressed. In addition, the genetic and bio-functional aspects as classifying parameters were included and established an experimental frame of comparisons.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Sialolithiasis

SUBMITTER: Jessie Guidry

LAB HEAD: Jessie J Guidry

PROVIDER: PXD012422 | Pride | 2020-04-16

REPOSITORIES: Pride

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			Action	DRS
	S1.msf	Msf
	S1.mzML	Mzml
	S1.mzid.gz	Mzid
	S1.pride.mgf.gz	Mgf
	S1.raw	Raw

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Publications

A comprehensive analysis of sialolith proteins and the clinical implications.

Busso Carlos S CS Guidry Jessie J JJ Gonzalez Jhanis J JJ Zorba Vassilia V Son Leslie S LS Winsauer Peter J PJ Walvekar Rohan R RR

Clinical proteomics 20200331

<h4>Background</h4>Sialolithiasis or salivary gland stones are associated with high clinical morbidity. The advances in the treatment of sialolithiasis has been limited, however, by our understanding of their composition. More specifically, there is little information regarding the formation and composition of the protein matrix, the role of mineralogical deposition, or the contributions of cell epithelium and secretions from the salivary glands. A better understanding of these stone characteris ...[more]

PMID: 32265614

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