Overexpression of the mycobacterial PknB Ser/Thr kinase uncovers its global regulatory role in mycolic acids biosynthesis and trafficking
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Escherichia Coli
SUBMITTER: 
Alexandre STELLA
LAB HEAD: Odile Schiltz
PROVIDER: PXD012553 | Pride | 2021-08-30
REPOSITORIES: Pride
Dataset's files
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|---|---|---|---|---|
| MaxQuant.7z | Other | |||
| QEAJS171123_03.raw | Raw | |||
| QEAJS171123_05.raw | Raw | |||
| QEAJS171123_08.raw | Raw | |||
| QEAJS171123_10.raw | Raw |
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Publications
The protein kinase PknB negatively regulates biosynthesis and trafficking of mycolic acids in mycobacteria.
Le Nguyen-Hung NH Locard-Paulet Marie M Stella Alexandre A Tomas Nicolas N Molle Virginie V Burlet-Schiltz Odile O Daffé Mamadou M Marrakchi Hedia H
Journal of lipid research 20200602 8
<i>Mycobacterium tuberculosis</i> is the causative agent of tuberculosis and remains one of the most widespread and deadliest bacterial pathogens in the world. A distinguishing feature of mycobacteria that sets them apart from other bacteria is the unique architecture of their cell wall, characterized by various species-specific lipids, most notably mycolic acids (MAs). Therefore, targeted inhibition of enzymes involved in MA biosynthesis, transport, and assembly has been extensively explored in ...[more]
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