Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: MODEL1109130000MODEL1311110000MODEL1909260003MODEL1311110001MODEL1909260004MODEL1703310000MODEL1909260005MODEL1909260006
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Johannes Gloeckner
LAB HEAD: Christian Johannes Gloeckner
PROVIDER: PXD012732 | Pride | 2020-03-25
REPOSITORIES: Pride
Action | DRS | |||
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GLO2216A2MA2-40-29070.RAW | Raw | |||
GLO2216A3MA2-40-29072.RAW | Raw | |||
GLO2216A4MA2-40-29074.RAW | Raw | |||
GLO2216_rev1.sf3 | Other |
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Nature communications 20200309 1
Regulation of mitosis secures cellular integrity and its failure critically contributes to the development, maintenance, and treatment resistance of cancer. In yeast, the dual phosphatase Cdc14 controls mitotic progression by antagonizing Cdk1-mediated protein phosphorylation. By contrast, specific mitotic functions of the mammalian Cdc14 orthologue CDC14B have remained largely elusive. Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase U ...[more]