Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
TISSUE(S): Cell Suspension Culture
SUBMITTER: Georg Borner
LAB HEAD: Georg H H Borner
PROVIDER: PXD012867 | Pride | 2019-03-13
REPOSITORIES: Pride
Items per page: 1 - 5 of 18 |
eLife 20190313
Misfolded proteins in the endoplasmic reticulum (ER) activate the unfolded protein response (UPR), which enhances protein folding to restore homeostasis. Additional pathways respond to ER stress, but how they help counteract protein misfolding is incompletely understood. Here, we develop a titratable system for the induction of ER stress in yeast to enable a genetic screen for factors that augment stress resistance independently of the UPR. We identify the proteasome biogenesis regulator Rpn4 an ...[more]