Proteomics

Dataset Information

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MonoMac6 (MM6) cells proteomics LC-MS/MS

ABSTRACT: MicroRNAs (miRs) are small non-coding RNAs, which control the expression of target genes by either translational repression or RNA degradation, known as canonical miR function. MiR-328 has a non-canonical function and can activate gene expression by antagonizing the activity of heterogeneous ribonuclear protein E2 (hnRNP E2). The global importance of such non-canonical miR function is not yet known. In order to achieve a better understanding of the non-canonical miR activity, a compartment specific tandem mass tag (TMT)-based proteomic analysis in differentiated MonoMac6 (MM6) cells was performed.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Cell Culture

SUBMITTER: Elena Ossipova  

LAB HEAD: Per-Johan Jakobsson

PROVIDER: PXD013106 | Pride | 2019-11-27

REPOSITORIES: Pride

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Publications

Mass Spectrometry-Based Proteomics Approach Characterizes the Dual Functionality of miR-328 in Monocytes.

Saul Meike J MJ   Hegewald Anett B AB   Emmerich Anne C AC   Ossipova Elena E   Vogel Marc M   Baumann Isabell I   Kultima Kim K   Lengqivst Johan J   Steinhilber Dieter D   Jakobsson Per Johan PJ  

Frontiers in pharmacology 20190605

MicroRNAs (miRs) are small noncoding RNAs which control the expression of target genes by either translational repression or RNA degradation, known as canonical miR functions. The recent discovery that miR-328 has a noncanonical function and can activate gene expression by antagonizing the activity of heterogeneous ribonuclear protein E2 (hnRNP E2) opens an unexplored and exciting field of gene expression regulation. The global importance of such noncanonical miR function is not yet known. In or  ...[more]

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