Dataset Information

Treatment-naïve type 2 diabetics metaproteomics

ABSTRACT: To gain further insights into functional changes in the gut microbiome associated with T2D, we conducted metaproteomic analyses using iTRAQ (isobaric peptide tags for relative and absolute quantification) and LC-MS/MS-based protocols on 84 samples

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Rongli Zhao

LAB HEAD: Junhua Li

PROVIDER: PXD013452 | Pride | 2019-09-11

REPOSITORIES: Pride

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Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naïve type 2 diabetics.

Zhong Huanzi H Ren Huahui H Lu Yan Y Fang Chao C Hou Guixue G Yang Ziyi Z Chen Bing B Yang Fangming F Zhao Yue Y Shi Zhun Z Zhou Baojin B Wu Jiegen J Zou Hua H Zi Jin J Chen Jiayu J Bao Xiao X Hu Yihe Y Gao Yan Y Zhang Jun J Xu Xun X Hou Yong Y Yang Huanming H Wang Jian J Liu Siqi S Jia Huijue H Madsen Lise L Brix Susanne S Kristiansen Karsten K Liu Fang F Li Junhua J

EBioMedicine 20190903

<h4>Background</h4>The gut microbiota plays important roles in modulating host metabolism. Previous studies have demonstrated differences in the gut microbiome of T2D and prediabetic individuals compared to healthy individuals, with distinct disease-related microbial profiles being reported in groups of different age and ethnicity. However, confounding factors such as anti-diabetic medication hamper identification of the gut microbial changes in disease development.<h4>Method</h4>We used a combi ...[more]

PMID: 31492563

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			Action	DRS
	meta_rep1.dat	Other
	meta_rep1.mgf	Mgf
	meta_rep1.mzid.gz	Mzid
	meta_rep1.pride.mgf.gz	Mgf
	meta_rep1.pride.mztab.gz	Mztab