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GRP75 in chicken - 75 kDa glucose-regulated protein (GRP75) is a novel molecular signature for heat stress response in avian species

ABSTRACT: GRP75 is a multipotent chaperone regulating cellular processes ranging from stress response to neurodegeneration. As the only ATPase component of the pre-protein mitochondrial import machinery, GRP75 plays a key role in multiple basic mitochondrial processes, including mitochondrial protein import, folding, and degradation. We are interested to characterize and study functions of GRP75 in avian using chicken as a model.

INSTRUMENT(S): maXis

ORGANISM(S): Gallus Gallus (chicken)

TISSUE(S): Liver

SUBMITTER: Ahmed Dhamad

LAB HEAD: Sami Dridi

PROVIDER: PXD013591 | Pride | 2019-12-16

REPOSITORIES: Pride

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			Action	DRS
	281474976713801 (liz_GR75_9_01_33).mzid_281474976713801_(liz_GR75_9_01_33).pride.mgf.gz	Mzid
	281474976713801 (liz_GR75_9_01_33).pride.mztab.gz	Mztab
	281474976713801_(liz_GR75_9_01_33).pride.mgf.gz	Mgf
	281474976713801_liz_GR75_9_01_33.mgf	Mgf
	281474976713801liz_GR75_9_01_33.mzid.gz	Mzid

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Publications

75-kDa glucose-regulated protein (GRP75) is a novel molecular signature for heat stress response in avian species.

Dhamad Ahmed Edan AE Greene Elizabeth E Sales Marites M Nguyen Phuong P Beer Lesleigh L Liyanage Rohana R Dridi Sami S

American journal of physiology. Cell physiology 20191204 2

Glucose-regulated protein 75 (GRP75) was first characterized in mammals as a heat shock protein-70 (HSP70) family stress chaperone based on its sequence homology. Extensive studies in mammals showed that GRP75 is induced by various stressors such as glucose deprivation, oxidative stress, and hypoxia, although it remained unresponsive to the heat shock. Such investigations are scarce in avian (nonmammalian) species. We here identified chicken GRP75 by using immunoprecipitation assay integrated wi ...[more]

PMID: 31800296

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