Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Hela Cell
SUBMITTER: Jonas Michaelis
LAB HEAD: Christian Münch
PROVIDER: PXD024066 | Pride | 2021-12-20
REPOSITORIES: Pride
Action | DRS | |||
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20210119_MAA_JM_E250_DDA.msf | Msf | |||
20210119_MAA_JM_E250_DDA.raw | Raw | |||
20210119_MAA_JM_E250_TMD.msf | Msf | |||
20210119_MAA_JM_E250_TMD.raw | Raw | |||
Proteinase_K_experiment_DDA_TMD_description.xlsx | Xlsx |
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Molecular cell 20211129 2
Most mitochondrial proteins are translated in the cytosol and imported into mitochondria. Mutations in the mitochondrial protein import machinery cause human pathologies. However, a lack of suitable tools to measure protein uptake across the mitochondrial proteome has prevented the identification of specific proteins affected by import perturbation. Here, we introduce mePROD<sup>mt</sup>, a pulsed-SILAC based proteomics approach that includes a booster signal to increase the sensitivity for mito ...[more]