Dataset Information
Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Cell, Bone Marrow
SUBMITTER: 
Xiaoxiao Huang
LAB HEAD: Neil L Kelleher
PROVIDER: PXD013759 | Pride | 2019-06-27
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Study1_NSD2BirA_bio1.mgf | Mgf | |||
| Study1_NSD2BirA_bio1.mzid.gz | Mzid | |||
| Study1_NSD2BirA_bio1.pride.mgf.gz | Mgf | |||
| Study1_NSD2BirA_bio1.pride.mztab.gz | Mztab | |||
| Study1_NSD2BirA_bio1.raw | Raw |
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Publications
Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.
The Journal of biological chemistry 20190627 33
NSD2 is a histone methyltransferase that specifically dimethylates histone H3 lysine 36 (H3K36me2), a modification associated with gene activation. Dramatic overexpression of NSD2 in t(4;14) multiple myeloma (MM) and an activating mutation of NSD2 discovered in acute lymphoblastic leukemia are significantly associated with altered gene activation, transcription, and DNA damage repair. The partner proteins through which NSD2 may influence critical cellular processes remain poorly defined. In this ...[more]
