Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Trypanosoma Brucei
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Sleeping Sickness
SUBMITTER: Martin Zoltner
LAB HEAD: Mark C. Field
PROVIDER: PXD014215 | Pride | 2020-04-30
REPOSITORIES: Pride
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Zoltner Martin M Campagnaro Gustavo D GD Taleva Gergana G Burrell Alana A Cerone Michela M Leung Ka-Fai KF Achcar Fiona F Horn David D Vaughan Sue S Gadelha Catarina C Zíková Alena A Barrett Michael P MP de Koning Harry P HP Field Mark C MC
The Journal of biological chemistry 20200430 24
Introduced about a century ago, suramin remains a frontline drug for the management of early-stage East African trypanosomiasis (sleeping sickness). Cellular entry into the causative agent, the protozoan parasite <i>Trypanosoma brucei</i>, occurs through receptor-mediated endocytosis involving the parasite's invariant surface glycoprotein 75 (ISG75), followed by transport into the cytosol via a lysosomal transporter. The molecular basis of the trypanocidal activity of suramin remains unclear, bu ...[more]