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Trypanosoma brucei rhodensience suramin resistance shotgun proteomics

ABSTRACT: Human African Trypanosomiasis (HAT) is a disease of major economic importance in Sub-Saharan Africa. In eastern and southern Africa. Here we analysed clinical isolates of T brucei rhodensiense, resistant to suramin by shotgun proteomics . And identified parasite proteins whose expression is associated with resistance to suramin.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Trypanosoma Brucei

TISSUE(S): Blood Cell, Whole Body

DISEASE(S): Trypanosomiasis

SUBMITTER: Martin Rono

LAB HEAD: Martin rono

PROVIDER: PXD021560 | Pride | 2021-09-09

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Rono_TMT_6plex.mgf	Mgf
	Rono_TMT_6plex.raw	Raw
	TriTrypDB-9.0_TbruceiTREU927_AnnotatedProteins.fasta	Fasta
	TriTrypDB-9.0_TbruceigambienseDAL972_AnnotatedProteins.fasta	Fasta
	WPSettings.dat	Other

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1 - 5 of 23

Publications

Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in Busoga, Uganda.

Mutuku Catherine N CN Bateta Rosemary R Rono Martin K MK Njunge James M JM Awuoche Erick O EO Ndung'u Kariuki K Mang'era Clarence M CM Akoth Modesta O MO Adung'a Vincent O VO Ondigo Bartholomew N BN Mireji Paul O PO

International journal for parasitology. Drugs and drug resistance 20210209

Human African Trypanosomiasis (HAT) is a disease of major economic importance in Sub-Saharan Africa. The HAT is caused by Trypanosoma brucei rhodesiense (Tbr) parasite in eastern and southern Africa, with suramin as drug of choice for treatment of early stage of the disease. Suramin treatment failures has been observed among HAT patients in Tbr foci in Uganda. In this study, we assessed Tbr parasite strains isolated from HAT patients responsive (Tbr EATRO-232) and non-responsive (Tbr EATRO-734) ...[more]

PMID: 33588295

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