Dataset Information
EndoC-betaH1 cells treated with interferon alpha
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Type B Pancreatic Cell, Cell Culture
DISEASE(S): Type 1 Diabetes Mellitus
SUBMITTER: 
Ernesto Nakayasu
LAB HEAD: Ernesto S. Nakayasu
PROVIDER: PXD014244 | Pride | 2020-04-15
REPOSITORIES: pride
Dataset's files
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Publications
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells.
Nature communications 20200522 1
Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. We presently characterize human beta cell responses to IFNα by combining ATAC-seq, RNA-seq and proteomics assays. The initial response to IFNα is characterized by chromatin remodeling, followed by changes in transcriptional and translational regulation. IFNα induces changes in alt ...[more]
