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Toxicoproteomics of environmental mixtures in prostate diseases

ABSTRACT: These data are from the following 2 experiments: 1. normal prostate stromal cells (BHPRS1) treated with either 0.1 uM mono(2-ethylhexyl) phthalate (MEHP), 3 uM perfluorooctanesulfonic acid (PFOS), the mixture of MEHP+PFOS, or DMSO vehicle (0.06% v/v); n=3 each 2. metastatic prostate epithelial cells (MT10) treated with 50 uM mono(2-ethylhexyl) phthalate (MEHP) or DMSO vehicle (0.06% v/v); n=4 each

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Prostate Gland Epithelium, Prostate Gland Stromal Cell

DISEASE(S): Prostate Cancer,Prostate Disease

SUBMITTER: Samuel Thomas

LAB HEAD: Lingjun Li

PROVIDER: PXD014428 | Pride | 2024-05-21

REPOSITORIES: Pride

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			Action	DRS
	1217_2015_UREA_DMSO1_1.raw	Raw
	1217_2015_UREA_DMSO1_2.raw	Raw
	1217_2015_UREA_DMSO2_1.raw	Raw
	1217_2015_UREA_DMSO2_2.raw	Raw
	1217_2015_UREA_DMSO3_1.raw	Raw

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Publications

Toxicoproteomics of Mono(2-ethylhexyl) phthalate and Perfluorooctanesulfonic Acid in Models of Prostatic Diseases.

Thomas Samuel S Ricke William A WA Li Lingjun L

Chemical research in toxicology 20230207 2

Benign and malignant prostatic diseases are common, costly, and burdensome; moreover, they share fundamental underlying molecular processes. Several ubiquitous contaminants may perturb these processes, possibly <i>via</i> peroxisome proliferator-activated receptor (PPAR) signaling, but the role of environmental exposures─particularly mixtures─in prostatic diseases is undefined. In the present study, nontumorigenic prostate stromal cells and metastatic prostate epithelial cells were exposed to ub ...[more]

PMID: 36749316

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