Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mycobacterium Tuberculosis C Stg4006
TISSUE(S): Cell Culture
SUBMITTER: Saima Ahmed
LAB HEAD: Hanno Steen
PROVIDER: PXD015197 | Pride | 2020-05-27
REPOSITORIES: Pride
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Zeng Jumei J Platig John J Cheng Tan-Yun TY Ahmed Saima S Skaf Yara Y Potluri Lakshmi-Prasad LP Schwartz Daniel D Steen Hanno H Moody D Branch DB Husson Robert N RN
PLoS pathogens 20200407 4
The Mycobacterium tuberculosis Ser/Thr protein kinases PknA and PknB are essential for growth and have been proposed as possible drug targets. We used a titratable conditional depletion system to investigate the functions of these kinases. Depletion of PknA or PknB or both kinases resulted in growth arrest, shortening of cells, and time-dependent loss of acid-fast staining with a concomitant decrease in mycolate synthesis and accumulation of trehalose monomycolate. Depletion of PknA and/or PknB ...[more]