Proteomics

Dataset Information

0

High-resolution proteomics of Zika and Dengue serum samples


ABSTRACT: We used data independent acquisition (DIA) mass spectrometry (MS) to profile ~800 proteinsfrom 122 serum samples Dengue or Zika Trinidadian patients. Two time points were collectedper patient. The DIA MS data were matched against a spectral library generated from high pH/low pH separated pooled serum samples.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Dengue Disease,Zika Fever

SUBMITTER: Shuvadeep Maity  

LAB HEAD: Christine Vogel

PROVIDER: PXD015422 | Pride | 2021-03-09

REPOSITORIES: Pride

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Publications


Distinguishing between Zika and dengue virus infections is critical for accurate treatment, but we still lack detailed understanding of their impact on their host. To identify new protein signatures of the two infections, we used next-generation proteomics to profile 122 serum samples from 62 Zika and dengue patients. We quantified >500 proteins and identified 13 proteins that were significantly differentially expressed (adjusted p-value < 0.05). These proteins typically function in infection an  ...[more]

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