Proteomics

Dataset Information

0

Yildirim 4398 Nup153 Interactome


ABSTRACT: Identify Nup153 interacting proteins in Co-IP coupled with LC-MS/MS

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Erik Soderblom  

LAB HEAD: Eda Yildirim

PROVIDER: PXD015441 | Pride | 2021-03-10

REPOSITORIES: Pride

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Publications

Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding.

Kadota Shinichi S   Ou Jianhong J   Shi Yuming Y   Lee Jeannie T JT   Sun Jiayu J   Yildirim Eda E  

Nature communications 20200525 1


Nucleoporin proteins (Nups) have been proposed to mediate spatial and temporal chromatin organization during gene regulation. Nevertheless, the molecular mechanisms in mammalian cells are not well understood. Here, we report that Nucleoporin 153 (NUP153) interacts with the chromatin architectural proteins, CTCF and cohesin, and mediates their binding across cis-regulatory elements and TAD boundaries in mouse embryonic stem (ES) cells. NUP153 depletion results in altered CTCF and cohesin binding  ...[more]

Shared Molecules

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