Identification of Bona Fide Targets of AMPylating Fic-enzymes by Substrate Mediated Covalent Capture
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Christoph Krisp
LAB HEAD: Azmelt tyen
PROVIDER: PXD015599 | Pride | 2020-07-09
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 180227_CK_BG_M1-_E1.raw | Raw | |||
| 180227_CK_BG_M1-_E2.raw | Raw | |||
| 180227_CK_BG_M1_E1.raw | Raw | |||
| 180227_CK_BG_M1_E2.raw | Raw | |||
| 180227_CK_BG_M2-_E1.raw | Raw |
Items per page: 5 1 - 5 of 43 |
Publications
Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture.
Gulen Burak B Rosselin Marie M Fauser Joel J Albers Michael F MF Pett Christian C Krisp Christoph C Pogenberg Vivian V Schlüter Hartmut H Hedberg Christian C Itzen Aymelt A
Nature chemistry 20200706 8
Various pathogenic bacteria use post-translational modifications to manipulate the central components of host cell functions. Many of the enzymes released by these bacteria belong to the large Fic family, which modify targets with nucleotide monophosphates. The lack of a generic method for identifying the cellular targets of Fic family enzymes hinders investigation of their role and the effect of the post-translational modification. Here, we establish an approach that uses reactive co-substrate- ...[more]
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