Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
DISEASE(S): Parkinson's Disease
SUBMITTER: TuKiet Lam
LAB HEAD: Sreeganga Chandra
PROVIDER: PXD016015 | Pride | 2020-05-26
REPOSITORIES: Pride
Items per page: 1 - 5 of 37 |
Proceedings of the National Academy of Sciences of the United States of America 20191104 48
Parkinson's disease is characterized by the aggregation of the presynaptic protein α-synuclein and its deposition into pathologic Lewy bodies. While extensive research has been carried out on mediators of α-synuclein aggregation, molecular facilitators of α-synuclein disaggregation are still generally unknown. We investigated the role of molecular chaperones in both preventing and disaggregating α-synuclein oligomers and fibrils, with a focus on the mammalian disaggregase complex. Here, we show ...[more]