Proteomics

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Extracellular vesicles (EV) from IFNγ-primed cardiosphere-derived cells (CDCs)

ABSTRACT: Characterization of proteins in extracellular vesicles (EV) from cardiosphere-derived cells (CDCs) of a clinically relevant pig model. Additionally, considering that priming stem cells with inflammatory stimuli may increase the therapeutic potential of released vesicles, here we studied the dynamic changes that take place in the EV from IFNγ-primed CDCs.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Stem Cell

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Inmaculada Jorge  

LAB HEAD: Javier García Casado

PROVIDER: PXD016434 | Pride | 2020-05-15

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Exos_Cardiosf_FR-ALL.msf Msf
Exos_Cardiosf_FR-ALL.raw Raw
Exos_Cardiosf_FR-ALL_bis.msf Msf
Exos_Cardiosf_FR-ALL_bis.raw Raw
Exos_Cardiosf_Fr1.msf Msf
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Publications

Experimental data demonstrated that the regenerative potential and immunomodulatory capacity of cardiosphere-derived cells (CDCs) is mediated by paracrine mechanisms. In this process, extracellular vesicles derived from CDCs (EV-CDCs) are key mediators of their therapeutic effect. Considering the future applicability of these vesicles in human diseases, an accurate preclinical-to-clinical translation is needed, as well as an exhaustive molecular characterization of animal-derived therapeutic pro  ...[more]

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