Dataset Information

OT1 T cell activation time course

ABSTRACT: Time course of OT1 T cell activation with SIINFEKL peptide.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spleen, T Cell, Lymph Node

SUBMITTER: Julia Marchingo

LAB HEAD: Doreen Ann Cantrell

PROVIDER: PXD016443 | Pride | 2020-02-25

REPOSITORIES: Pride

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Publications

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation.

Marchingo Julia M JM Sinclair Linda V LV Howden Andrew Jm AJ Cantrell Doreen A DA

eLife 20200205

T cell expansion and differentiation are critically dependent on the transcription factor c-Myc (Myc). Herein we use quantitative mass-spectrometry to reveal how Myc controls antigen receptor driven cell growth and proteome restructuring in murine T cells. Analysis of copy numbers per cell of >7000 proteins provides new understanding of the selective role of Myc in controlling the protein machinery that govern T cell fate. The data identify both Myc dependent and independent metabolic processes ...[more]

PMID: 32022686

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