Proteomics

Dataset Information

0

Data Set2: Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D

ABSTRACT: RAW files of corresponding Baits used in Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D

INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Colon Cancer

SUBMITTER: Mohamed Ali Jarboui  

LAB HEAD: Mohamed ali Jarboui

PROVIDER: PXD016461 | Pride | 2019-12-03

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
030314_CR_01_MAP2K7_REV1.raw Raw
030314_CR_01_MAP2K7_REV1b.raw Raw
030314_CR_01_MAP2K7_REV2.raw Raw
030314_CR_01_MAP2K7_REV2b.raw Raw
030314_CR_01_MAP2K7_REV3.raw Raw
Items per page:
1 - 5 of 27
altmetric image

Publications

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS<sup>G13D</sup>.

Kennedy Susan A SA   Jarboui Mohamed-Ali MA   Srihari Sriganesh S   Raso Cinzia C   Bryan Kenneth K   Dernayka Layal L   Charitou Theodosia T   Bernal-Llinares Manuel M   Herrera-Montavez Carlos C   Krstic Aleksandar A   Matallanas David D   Kotlyar Max M   Jurisica Igor I   Curak Jasna J   Wong Victoria V   Stagljar Igor I   LeBihan Thierry T   Imrie Lisa L   Pillai Priyanka P   Lynn Miriam A MA   Fasterius Erik E   Al-Khalili Szigyarto Cristina C   Breen James J   Kiel Christina C   Serrano Luis L   Rauch Nora N   Rukhlenko Oleksii O   Kholodenko Boris N BN   Iglesias-Martinez Luis F LF   Ryan Colm J CJ   Pilkington Ruth R   Cammareri Patrizia P   Sansom Owen O   Shave Steven S   Auer Manfred M   Horn Nicola N   Klose Franziska F   Ueffing Marius M   Boldt Karsten K   Lynn David J DJ   Kolch Walter W  

Nature communications 20200124 1

Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRAS<sup>G13D</sup>) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is extensively rewired in cells expressing tran  ...[more]

Similar Datasets

Proteomics Data Set: Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
2019-12-04 | PXD016464 | Pride
Proteomics Data Set3: Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
2019-12-02 | PXD016462 | Pride
Proteomics Data Set3: Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
2019-12-03 | PXD016463 | Pride
Proteomics Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
2019-12-02 | PXD016505 | Pride
Proteomics : Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
2019-12-03 | PXD016512 | Pride
Proteomics Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
2019-12-02 | PXD016465 | Pride
Proteomics mTOR inhibition via Rapamycin treatment partially reverts the deficit in energy metabolism caused by FH loss in RPE cells
2022-02-16 | PXD029408 | Pride
Proteomics A role for the Trim33 ubiquitin ligase in cellular response to replicative stress
2023-07-24 | PXD037854 | Pride
Proteomics Cirl Interactome in Drososphila
2023-01-16 | PXD033873 | Pride
Proteomics Comparative proteomics for identification of type I interferon response in primary human glioblastoma multiforme cells
2022-02-03 | PXD022906 | Pride