Dataset Information

Analysis of protein expression in the lung of mice infected with influenza virus(WSN)

ABSTRACT: In order to analysis the changes of protein expression and its influence on innate immune in mice lung after influenza virus infection,we detect protein expression profile by iTRAQ method

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

SUBMITTER: Biao Chen

LAB HEAD: Ji-Long Chen

PROVIDER: PXD017061 | Pride | 2020-07-06

REPOSITORIES: Pride

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Publications

Robust expression of p27Kip1 induced by viral infection is critical for antiviral innate immunity.

Rai Kul Raj KR Chen Biao B Zhao Zhonghui Z Chen Yuhai Y Hu Jiayue J Liu Shasha S Maarouf Mohamed M Li Yingying Y Xiao Meng M Liao Yuan Y Chen Ji-Long JL

Cellular microbiology 20200801 11

Influenza A virus (IAV) infection regulates the expression of numerous host genes. However, the precise mechanism underlying implication of these genes in IAV pathogenesis remains largely unknown. Here, we employed isobaric tags for relative and absolute quantification (iTRAQ) to identify host proteins regulated by IAV infection. iTRAQ analysis of mouse lungs infected or uninfected with IAV showed a total of 167 differentially upregulated proteins in response to the viral infection. Interestingl ...[more]

PMID: 32596986

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