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The pan-Sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line

ABSTRACT: The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction has emerged as having a key role in a number of human diseases, including cancer. Here, we investigated mitochondrial damage resulting from treatment with a recently characterized pan-SIRT inhibitor, MC2494. MC2494 was able to block mitochondrial biogenesis and function in terms of ATP synthesis and energy metabolism, suggesting that it might orchestrate cell response to metabolic stress and thereby interfere with tumorigenesis. Targeting mitochondrial function could thus be considered a potential anticancer strategy for use in clinical therapy.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Monocyte, Cell Culture

DISEASE(S): Acute Leukemia,Lymphoma

SUBMITTER: Angela Chambery

LAB HEAD: Angela Chambery

PROVIDER: PXD017508 | Pride | 2021-09-08

REPOSITORIES: Pride

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The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line.

Carafa Vincenzo V Russo Rosita R Della Torre Laura L Cuomo Francesca F Dell'Aversana Carmela C Sarno Federica F Sgueglia Giulia G Di Donato Marzia M Rotili Dante D Mai Antonello A Nebbioso Angela A Cobellis Gilda G Chambery Angela A Altucci Lucia L

Frontiers in oncology 20200521

The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction has emerged as having a key role in a number of human diseases, including cancer. Here, we investigated mitochondrial damage resulting from treatment with a recently characterized pan-SIRT inhibitor, ...[more]

PMID: 32528892

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			Action	DRS
	TMT_U937_search.msf	Msf
	U937_TMT_1.raw	Raw
	U937_TMT_2.raw	Raw
	U937_TMT_3.raw	Raw