Proteomics

Dataset Information

0

Altered bovine lymphocyte secretome after pokeweed mitogen stimulation


ABSTRACT: Vaccination with a new vaccine against bovine viral diarrhea (BVD) caused unwanted immune reactions through alloreactive antibody production in 5–10% of vaccinated cows. Transfer of these alloreactive antibodies via colostrum caused highly lethal (90%) bovine neonatal pancytopenia (BNP) in calves. Despite the assumption of an immune deviant lymphocyte (PBL) phenotype, the exact immunological mechanisms driving these unwanted immune reactions are not fully understood to date. To gain deeper insight into these mechanisms, we analyzed the PBL secretome from alloreactive antibody producers (BNP cows) and non-alloreactive responders (controls) after stimulation with pokeweed mitogen (PWM).

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Leukocyte, Blood

SUBMITTER: Roxane Degroote  

LAB HEAD: Cornelia Annette Deeg

PROVIDER: PXD017892 | Pride | 2022-02-10

REPOSITORIES: Pride

Similar Datasets

2022-02-10 | PXD017350 | Pride
2023-03-10 | PXD036881 | Pride
2024-03-01 | GSE249197 | GEO
2023-01-16 | PXD037755 | Pride
2021-01-19 | GSE165039 | GEO
2020-11-04 | GSE160721 | GEO
2015-08-05 | GSE71696 | GEO
2014-07-17 | E-GEOD-57418 | biostudies-arrayexpress
2014-07-17 | E-GEOD-57400 | biostudies-arrayexpress
2024-10-09 | E-MTAB-14450 | biostudies-arrayexpress