Proteomics

Dataset Information

0

Mycobacterium avium subsp. paratuberculosis infected cows reveal divergent immune response in bovine peripheral blood derived lymphocyte proteome


ABSTRACT: Bovine paratuberculosis is a serious chronic disease of the gastrointestinal tract caused by Mycobacterium avium subspecies paratuberculosis (MAP). The aim of this study was to detect proteomic changes in peripheral blood mononuclear cells (PBMC) from cows of the same herd with different MAP infection status after co-incubation with viable MAP in vitro using label-free LC-MS/MS. Our data contribute to a better understanding of the bovine immune response and mechanisms of susceptibility to MAP.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Peripheral Blood Mononuclear Cell, Leukocyte, Blood

SUBMITTER: Roxane Degroote  

LAB HEAD: Stefanie M Hauck

PROVIDER: PXD036881 | Pride | 2023-03-10

REPOSITORIES: Pride

altmetric image

Publications

<i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> Infected Cows Reveal Divergent Immune Response in Bovine Peripheral Blood Derived Lymphocyte Proteome.

Korbonits Lucia L   Kleinwort Kristina J H KJH   Amann Barbara B   Didier Andrea A   Märtlbauer Erwin E   Hauck Stefanie M SM   Deeg Cornelia A CA  

Metabolites 20220929 10


Bovine paratuberculosis is a serious chronic disease of the gastrointestinal tract that causes economic losses and dramatically affects animal health in livestock. The underlying infectious agent, <i>Mycobacterium avium</i> subspecies <i>paratuberculosis</i> (MAP), cannot reliably be detected by standard diagnostic tests due to the long asymptomatic disease stage. The aim of this study was to detect proteomic changes in peripheral blood mononuclear cells (PBMC) from cows of the same herd with di  ...[more]

Similar Datasets

2021-08-26 | PXD027444 | Pride
2023-07-20 | PXD038772 | Pride
2010-10-31 | E-MEXP-2865 | biostudies-arrayexpress
2020-06-18 | PXD017248 | Pride
2012-12-29 | E-GEOD-43182 | biostudies-arrayexpress
2014-11-20 | PXD001159 | Pride
2012-05-31 | E-GEOD-32242 | biostudies-arrayexpress
2012-11-29 | E-GEOD-32235 | biostudies-arrayexpress
2012-05-31 | E-GEOD-32241 | biostudies-arrayexpress
2023-04-19 | PXD039554 | Pride