Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell
DISEASE(S): Human Immunodeficiency Virus Infectious Disease
SUBMITTER: James Williamson
LAB HEAD: Nicholas J Matheson
PROVIDER: PXD018271 | Pride | 2020-04-17
REPOSITORIES: Pride
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eLife 20200415
The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. We recently reported that HIV-1 Vif is also able to degrade the PPP2R5 family of regulatory subunits of key cellular phosphatase PP2A (PPP2R5A-E; Greenwood et al., 2016; Naamati et al., 2019). We now identify amino acid polymorphisms at positions 31 and 128 of HIV-1 Vif which selectively regulate the degradation of PPP2R5 famil ...[more]