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Quantitative analysis of skin proteomics in Chinese young and old populations by mass spectrometry

ABSTRACT: Aging is a normal physiological phenomenon of organisms. Skin aging is a specific manifestation of aging of local human organs. In this study, we used mass spectrometry to perform non-invasive analysis of the skin of 20 healthy young and elderly people in China. Quantitative proteomic analysis identified differentially expressed proteins.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin

SUBMITTER: MA JING

LAB HEAD: SEN YANG

PROVIDER: PXD018430 | Pride | 2020-08-05

REPOSITORIES: Pride

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Publications

Quantitative proteomics analysis of young and elderly skin with DIA mass spectrometry reveals new skin aging-related proteins.

Ma Jing J Liu Mengting M Wang Yaochi Y Xin Cong C Zhang Hui H Chen Shirui S Zheng Xiaodong X Zhang Xuejun X Xiao Fengli F Yang Sen S

Aging 20200629 13

Skin aging is a specific manifestation of the physiological aging process that occurs in virtually all organisms. In this study, we used data independent acquisition mass spectrometry to perform a comparative analysis of protein expression in volar forearm skin samples from of 20 healthy young and elderly Chinese individuals. Our quantitative proteomic analysis identified a total of 95 differentially expressed proteins (DEPs) in aged skin compared to young skin. Enrichment analyses of these DEPs ...[more]

PMID: 32602849

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