Dataset Information

H. sapiens First trimester placental villous explant 0conditioned media; galectin-7/BSA treatment; 2% O2

ABSTRACT: Identification of factors in conditioned media of first-trimester placental villous explants. Explants were cultured under hypoxia (2% O2), 5% CO2 in serum-free DMEM/F12 and treated with recombinant galectin-7 (1ug/ml) or vehicle control (BSA) for 72h. Identification of factors in conditioned media of first-trimester placental villous explants. Explants were cultured under superoxia (20% O2), 5% CO2 in serum-free DMEM/F12 and treated with recombinant galectin-7 (1ug/ml) or vehicle control (BSA) for 72h.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Placenta

SUBMITTER: Swati Varshney

LAB HEAD: Eva Dimitriadis

PROVIDER: PXD019331 | Pride | 2021-04-20

REPOSITORIES: pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	190923_Ellen_DMEM_F12_1_PS.raw	Raw
	190923_Ellen_P018_VEHC.raw	Raw
	190923_Ellen_P374_20per_BSA.raw	Raw
	190923_Ellen_P374_20per_G7.raw	Raw
	190923_Ellen_P374_2per_BSA.raw	Raw

Items per page:

1 - 5 of 18

Publications

Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice.

Menkhorst Ellen E Zhou Wei W Santos Leilani L LL Delforce Sarah S So Teresa T Rainczuk Kate K Loke Hannah H Syngelaki Argyro A Varshney Swati S Williamson Nicholas N Pringle Kirsty K Young Morag J MJ Nicolaides Kypros H KH St-Pierre Yves Y Dimitriadis Eva E

Hypertension (Dallas, Tex. : 1979) 20200831 4

Preeclampsia is a serious pregnancy-induced disorder unique to humans. The etiology of preeclampsia is poorly understood; however, poor placental formation is thought causal. Galectin-7 is produced by trophoblast and is elevated in first-trimester serum of women who subsequently develop preeclampsia. We hypothesized that elevated placental galectin-7 may be causative of preeclampsia. Here, we demonstrated increased galectin-7 production in chorionic villous samples from women who subsequently de ...[more]

PMID: 32862708

Dataset Information

H. sapiens First trimester placental villous explant 0conditioned media; galectin-7/BSA treatment; 2% O2

Dataset's files

Publications

Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice.

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