Proteomics

Dataset Information

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Interactome analysis of human RBMS1 protein in SW480 cells.

ABSTRACT: To identify protein binding partners of endogenous RBMS1, it was immunoprecipicated in triplicate, vs. IgG control, from SW480 colon adenocarcinoma cells, and subjected to MS analysis on an Q-exactive plus Orbitrap mass spectrometer. Raw files 13, 14, and 15 correspond to biological replicate IPs of RBMS1, and Raw files 16, 17, and 18 correspond to biological replicate IPs of IgG control.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Colon Cancer

SUBMITTER: Faraz Mardakheh  

LAB HEAD: Faraz K. Mardakheh

PROVIDER: PXD019479 | Pride | 2020-06-10

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
QE2_20190712_mad_alberta_FASP_AN2-13.raw Raw
QE2_20190712_mad_alberta_FASP_AN2-14.raw Raw
QE2_20190712_mad_alberta_FASP_AN2-15.raw Raw
QE2_20190712_mad_alberta_FASP_AN2-16.raw Raw
QE2_20190712_mad_alberta_FASP_AN2-17.raw Raw
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Publications

Identifying master regulators that drive pathologic gene expression is a key challenge in precision oncology. Here, we have developed an analytic framework, named PRADA, that identifies oncogenic RNA-binding proteins through the systematic detection of coordinated changes in their target regulons. Application of this approach to data collected from clinical samples, patient-derived xenografts, and cell line models of colon cancer metastasis revealed the RNA-binding protein RBMS1 as a suppressor  ...[more]

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