Proteomics

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The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice - Proteomics results


ABSTRACT: In this study, mice were colonized from birth on with the minimal microbiota Oligo-MM with or without the addition of Extibacter muris. Extibacter muris is known to metabolize cholic acid to deoxycholic acid via 7α-dehydroxylation. The impact of Extibacter muris colonization on the liver proteome of mice under different diets was investigated using untargeted proteomics.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Isabel Karkossa  

LAB HEAD: Kristin Schubert

PROVIDER: PXD019973 | Pride | 2021-01-04

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
ExperimentalDesign.xlsx Xlsx
Leber_Aachen_10.mgf Mgf
Leber_Aachen_10.raw Raw
Leber_Aachen_11_181105191311.mgf Mgf
Leber_Aachen_11_181105191311.raw Raw
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Publications


<i>Extibacter muris</i> is a newly described mouse gut bacterium which metabolizes cholic acid (CA) to deoxycholic acid (DCA) via 7α-dehydroxylation. Although bile acids influence metabolic and inflammatory responses, few <i>in vivo</i> models exist for studying their metabolism and impact on the host. Mice were colonized from birth with the simplified community Oligo-MM<sup>12</sup> with or without <i>E. muris</i>. As the metabolism of bile acids is known to affect lipid homeostasis, mice were  ...[more]

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