Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Colon Cancer
SUBMITTER: Alexei Arnaoutov
LAB HEAD: Mary Dasso
PROVIDER: PXD020075 | Pride | 2020-06-30
REPOSITORIES: Pride
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DLDLMB_LFQ.raw | Raw | |||
DLD_LFQ.raw | Raw | |||
DescriptionofcolumnsforResultsspreadsheet.docx | Other |
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Nature communications 20200911 1
Nuclear pore complexes (NPCs) are important for cellular functions beyond nucleocytoplasmic trafficking, including genome organization and gene expression. This multi-faceted nature and the slow turnover of NPC components complicates investigations of how individual nucleoporins act in these diverse processes. To address this question, we apply an Auxin-Induced Degron (AID) system to distinguish roles of basket nucleoporins NUP153, NUP50 and TPR. Acute depletion of TPR causes rapid and pronounce ...[more]