Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Bone, Bone Marrow
SUBMITTER: Julia Löffler
LAB HEAD: Stefan Kempa
PROVIDER: PXD020085 | Pride | 2023-05-10
REPOSITORIES: Pride
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Communications biology 20230327 1
Bone regeneration after fracture is a complex process with high and dynamic energy demands. The impact of metabolism on bone healing progression and outcome, however, is so far understudied. Our comprehensive molecular profiling reveals that central metabolic pathways, such as glycolysis and the citric acid cycle, are differentially activated between rats with successful or compromised bone regeneration (young versus aged female Sprague-Dawley rats) early in the inflammatory phase of bone healin ...[more]