Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Pseudomonas Aeruginosa Pao1
SUBMITTER: Lauriane Kuhn
LAB HEAD: Isabelle Schalk
PROVIDER: PXD031065 | Pride | 2022-10-28
REPOSITORIES: Pride
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2019_S32_Sarah_3CPAc_3_500ng.raw | Raw | |||
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ACS infectious diseases 20220502 6
The development of new antibiotics against Gram-negative bacteria has to deal with the low permeability of the outer membrane. This obstacle can be overcome by utilizing siderophore-dependent iron uptake pathways as entrance routes for antibiotic uptake. Iron-chelating siderophores are actively imported by bacteria, and their conjugation to antibiotics allows smuggling the latter into bacterial cells. Synthetic siderophore mimetics based on MECAM (1,3,5-<i>N</i>,<i>N</i>',<i>N</i>″-tris-(2,3-dih ...[more]